Daniel Amador-Noguez
Associate Professor of Bacteriology
Impact of microbial bile acid transformations on host physiology
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Science advances.
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Science (New York, N.Y.).
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mSphere.
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Infection and immunity.
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Gut microbes.
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bioRxiv : the preprint server for biology.
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mSystems.
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mSystems.
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Nature communications.
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Gut microbes.
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Microbiology spectrum.
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mBio.
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Metabolic engineering.
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bioRxiv : the preprint server for biology.
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Gut microbes.
The metabolic activities of microbes have shaped the evolution of life on Earth, they touch every aspect of our daily existence and have an enormous impact on the environment, agriculture, biotechnology, and human health. Our research program seeks to generate a quantitative and holistic understanding of how metabolic networks are regulated in microbes. We integrate systems-level approaches, especially LC-MS-based metabolomics, with computational modeling and genetic engineering to understand how metabolic fluxes are controlled and how microbes adapt their metabolism in response to environmental challenges and during developmental processes. My laboratory has two several research areas, including metabolic regulation in biofuel producers, metabolic remodeling during biofilm development, biochemical activity of the gut microbiome.