Dawn Davis

Professor of Medicine

Changes in pancreatic beta cell gene expression in response to obesity and in the setting of beta cell proliferation

dbd@medicine.wisc.edu

Website

UW Med Fndtn Centennial Bldg
1685 Highland Ave 4142
Madison WI 53705-2281

Type: Faculty Trainer, MANTP Trainer

Department: School of Medicine and Public Health

University of Chicago Pritzker School of Medicine, Chicago, Illinois – MD

University of Chicago, Chicago, Illinois – PhD in Pathology

University of Washington Medical Center, Seattle, Washington – Residency in Internal Medicine

University of Wisconsin Hospital and Clinics – Fellowship in Endocrinology, Diabetes, and Metabolism

Rational Design and Evaluation of Novel TGR5 Agonists for Diabetes

Rachana S Bhimanwar, Zachary Detwiler, Jinge G Zhu, Samuel T Saghafi, Carolyn A Winder, Dawn Belt Davis, Amit Mittal, Vikas Sharma, David A Harris, Snehal N Chaudhari

Molecules (Basel, Switzerland). 2026 April 14.
The prostaglandin E2 EP3 receptor has disparate effects on islet insulin secretion and content in β-cells in a high-fat diet-induced mouse model of obesity

Joshua C Neuman, Austin Reuter, Kathryn A Carbajal, Michael D Schaid, Grant Kelly, Kelsey Connors, Cecilia Kaiser, Joshua Krause, Liam D Hurley, Angela Olvera, Dawn Belt Davis, Jaclyn A Wisinski, Maureen Gannon, Michelle E Kimple

American journal of physiology. Endocrinology and metabolism. 2024 March 13.
What the BTBR/J mouse has taught us about diabetes and diabetic complications

Mark P Keller, Kelly L Hudkins, Anath Shalev, Sushant Bhatnagar, Melkam A Kebede, Matthew J Merrins, Dawn Belt Davis, Charles E Alpers, Michelle E Kimple, Alan D Attie

iScience. 2023 June 26.
Metformin Monotherapy Alters the Human Plasma Lipidome Independent of Clinical Markers of Glycemic Control and Cardiovascular Disease Risk in a Type 2 Diabetes Clinical Cohort

Benjamin Wancewicz, Yanlong Zhu, Rachel J Fenske, Alicia M Weeks, Kent Wenger, Samantha Pabich, Michael Daniels, Margaret Punt, Randall Nall, Darby C Peter, Allan Brasier, Elizabeth D Cox, Dawn Belt Davis, Ying Ge, Michelle E Kimple

The Journal of pharmacology and experimental therapeutics. 2023 March 14.
Plasma Prostaglandin E2 Metabolite Levels Predict Type 2 Diabetes Status and One-Year Therapeutic Response Independent of Clinical Markers of Inflammation

Rachel J Fenske, Alicia M Weeks, Michael Daniels, Randall Nall, Samantha Pabich, Allison L Brill, Darby C Peter, Margaret Punt, Elizabeth D Cox, Dawn Belt Davis, Michelle E Kimple

Metabolites. 2022 December 23.
Pancreatic Stellate Cells Prolong Ex Vivo Islet Viability and Function and Improve Engraftment

Pradyut K Paul, Rahul Das, Travis J Drow, Arnaldo H de Souza, Appakalai N Balamurugan, Dawn Belt Davis, Jacques Galipeau

Stem cells translational medicine. 2022 April 19.
Cholecystokinin attenuates β-cell apoptosis in both mouse and human islets

Hung Tae Kim, Arnaldo H Desouza, Heidi Umhoefer, Jeeyoung Han, Lucille Anzia, Steven J Sacotte, Rashaun A Williams, Joseph T Blumer, Jacob T Bartosiak, Danielle A Fontaine, Mieke Baan, Carly R Kibbe, Dawn Belt Davis

Translational research : the journal of laboratory and clinical medicine. 2021 November 6.
TCF19 Impacts a Network of Inflammatory and DNA Damage Response Genes in the Pancreatic β-Cell

Grace H Yang, Danielle A Fontaine, Sukanya Lodh, Joseph T Blumer, Avtar Roopra, Dawn Belt Davis

Metabolites. 2021 August 26.
PREVENT: A Randomized, Placebo-controlled Crossover Trial of Avexitide for Treatment of Postbariatric Hypoglycemia

Colleen M Craig, Helen Margaret Lawler, Clare Jung Eun Lee, Marilyn Tan, Dawn Belt Davis, Jenny Tong, Michele Glodowski, Elisa Rogowitz, Rowan Karaman, Tracey L McLaughlin, Lisa Porter

The Journal of clinical endocrinology and metabolism. 2021 February 22.
Pyruvate Kinase Controls Signal Strength in the Insulin Secretory Pathway

Sophie L Lewandowski, Rebecca L Cardone, Hannah R Foster, Thuong Ho, Evgeniy Potapenko, Chetan Poudel, Halena R VanDeusen, Sophia M Sdao, Tiago C Alves, Xiaojian Zhao, Megan E Capozzi, Arnaldo H de Souza, Ishrat Jahan, Craig J Thomas, Craig S Nunemaker, Dawn Belt Davis, Jonathan E Campbell, Richard G Kibbey, Matthew J Merrins

Cell metabolism. 2020 November 4.
Intra-islet GLP-1, but not CCK, is necessary for β-cell function in mouse and human islets

Arnaldo Henrique de Souza, Jiayin Tang, Amanjot Kaur Yadev, Samuel T Saghafi, Carly R Kibbe, Amelia K Linnemann, Matthew J Merrins, Dawn Belt Davis

Scientific reports. 2020 February 20.
Imaging and therapy of diabetes: State of the art

Weibo Cai, Dawn Belt Davis

Advanced drug delivery reviews. 2019 August 4.
Roux en Y gastric bypass hypoglycemia resolves with gastric feeding or reversal: Confirming a non-pancreatic etiology

Dawn Belt Davis, Jad Khoraki, Martynas Ziemelis, Sirinart Sirinvaravong, Jee Young Han, Guilherme M Campos

Molecular metabolism. 2018 February 17.
Interleukin 6 protects pancreatic β cells from apoptosis by stimulation of autophagy

Amelia K Linnemann, Joseph Blumer, Michelle R Marasco, Therese J Battiola, Heidi M Umhoefer, Jee Young Han, Dudley W Lamming, Dawn Belt Davis

FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2017 June 9.
Successful in vitro fertilization and generation of transgenics in Black and Tan Brachyury (BTBR) mice

Mieke Baan, Kathleen J Krentz, Danielle A Fontaine, Dawn Belt Davis

Transgenic research. 2016 August 13.

Dr. Davis runs a federally funded research lab focused on pancreatic beta cell biology. Understanding the mechanisms underlying beta cell growth, survival and death may help identify new therapeutic targets that can help drive beta cell proliferation in the patient with prediabetes, type 2 diabetes, a recent islet transplant, or potentially even type 1 diabetes in combination with immune therapies. She also conducts collaborative clinical research that investigates biomarkers for diabetes, novel dietary interventions for weight loss and diabetes prevention, and the treatment of diabetes in hospitalized patients.

Dr. Dawn Davis is a tenured Professor in the Division of Endocrinology, Diabetes, and Metabolism within the Department of Medicine. She is also the Endocrinology Section Chief at the William S. Middleton Memorial VA Hospital. Dr. Davis is the Director of the UW-Madison Comprehensive Diabetes Center, which focuses on building research collaborations and opportunities across multiple schools and departments at UW-Madison. She has received a Puestow Research Award and a Dickie Research Award from the Department of Medicine, a UW Health Patient Experience Physician Champion Award, and a Junior Physician Investigator Award and Medical Research Scholar Award from the American Federation for Medical Research. She holds a Senior Clinician Scientist Investigator Award from the Department of Veterans Affairs for her distinguished service and research accomplishments in support of Veterans.