Nutrition and Metabolism Graduate Program

    College of Agricultural & Life Sciences

    UNIVERSITY of WISCONSIN-MADISON UW-MADISON

    Dudley Lamming

    Associate Professor of Endocrinology

    The regulation of healthy aging by what, when, and how much we eat

    dlamming@medicine.wisc.edu

    Website

    4147 UW Med Fndtn Centennial Bldg
    1685 Highland Ave

    Type: ,
    Department:

    Education

    • BS, Massachusetts Institute of Technology
    • PhD, Harvard University
    • Postdoc, Whitehead Institute for Biomedical Research
    • Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

      Mariah F Calubag, Ismail Ademi, Cara L Green, Dulmalika N H Manchanayake, Hashan S M Jayarathne, Ryan N Marshall, Sandra M Le, Penelope Lialios, Lucia E Breuer, Shoshana Yakar, Reji Babygirija, Michelle M Sonsalla, Isaac Grunow, Chung-Yang Yeh, Yang Liu, Bailey A Knopf, Sarah Yandell, Charles I Opara, William A Ricke, Teresa T Liu, Mark P Keller, Alan D Attie, Marianna Sadagurski, Dudley W Lamming

      Nature aging.

    • The association of frailty with age and lifespan in mice differs by strain and sex

      Dantong Zhu, Cara L Green, Sarah J Mitchell, Michael R MacArthur, Elise S Bisset, John Mach, Judy Z Wu, Brady A Samuelson, Anastasia Shindyapina, Alibek Moldakozhayev, Albina Tskhay, Alexander Tyshkovskiy, Vadim N Gladyshev, David A Sinclair, Susan E Howlett, Sarah N Hilmer, Dudley W Lamming, Alice E Kane

      The journals of gerontology. Series A, Biological sciences and medical sciences.

    • Bench to bedside: is rapamycin headed for the docTOR?

      Dudley W Lamming

      GeroScience.

    • Examining widely held propositions on human dietary protein needs and benefits: a critical review of the science that shapes both the data and our understanding of an essential macronutrient

      Mitchell M Kanter, Sally Aaron, Steven N Austad, Andrew W Brown, Nicholas A Burd, Wayne W Campbell, Mark Cope, Teresa A Davis, John W Erdman, Miguel Freitas, Kristen Hicks-Roof, Samuel Klein, Wantanee Kriengsinyos, Dudley W Lamming, Donald K Layman, Heather J Leidy, Kevin C Maki, Richard D Mattes, Shalene McNeill, Daniel R Moore, Stefan M Pasiakos, Stuart M Phillips, David Raubenheimer, Wendy Reinhardt, Nancy R Rodriguez, Stephen Simpson, Hans H Stein, Luc J C van Loon, Connie M Weaver, David B Allison

      Critical reviews in food science and nutrition.

    • Sleeve gastrectomy improves metabolic health, cognition, and Alzheimer’s Disease pathology in 3xTG mice

      Reji Babygirija, Julia A Illiano, Michelle M Sonsalla, Grace Zhu, Twinkle Mathew, Tristan Molkentin, Meredith Peterson, Carolyn Winder, Fan Xiao, Justin M Wolter, Dudley W Lamming, David A Harris

      bioRxiv : the preprint server for biology.

    • Female resistance to the metabolic benefits of protein restriction is reversed by ovariectomy in mice

      Bailey A Knopf, Isaac Grunow, Brady Anderson, Tareq Rihawi, Michelle M Sonsalla, Mariah F Calubag, Reji Babygirija, Yang Liu, Fan Xiao, Chung-Yang Yeh, Dudley W Lamming

      bioRxiv : the preprint server for biology.

    • Toward actionable interventions in human aging (12th ARDD meeting, 2025)

      Aleksandr Dekan, Sierra Lore, Ye Eun Yoon, Aisyah Sjöholm, Alexander Tyshkovskiy, Alexey Terskikh, Ana Maria Cuervo, Anastasia Georgievskaya, Andrea Heinz, Andrei Seluanov, Andrew Adams, Andy P Tsai, Anna Murray, Anne Brunet, Anne Marije van Harten, Avi Spier, Ben Shenhar, Bente Klarlund Pedersen, Berthil Clasen, Björn Schumacher, Brian K Kennedy, Charlotte Suetta, Christiane Volbracht, Christoph Kuppe, Clive Cookson, Collin Y Ewald, Cristiana Banila, Daisy Cai, Dario Riccardo Valenzano, Dudley W Lamming, Edward Rudnic, Elias Bou Samra, Emma Teeling, Eric Verdin, Evandro Fei Fang, Fabrizio d’Adda di Fagagna, Fedor Galkin, Garri Zmudze, Heinrich Jasper, In Hwa Jang, Jing-Dong Jackie Han, Jamie Justice, Jan H J Hoeijmakers, Javier María Peralta Ramos, Jean-Marc Lemaitre, Jeroen Aerssens, Joe Betts-LaCroix, John C Newman, Juan Carlos Izpisua Belmonte, Kazuto Kawamura, Kennedy Matsagas Schaal, Kitsu Egerton, Kotb Abdelmohsen, Kristen Fortney, Lars Hartenstein, Laura Niedernhofer, Lida Katsimpardi, Lisa Melton, Lotte Bjerre Knudsen, Luigi Ferrucci, Lykke Sylow, Marco Demaria, Marissa J Schafer, Marta Guasch-Ferré, Martin Borch-Jensen, Maxim Kholin, Michael Antonov, Michael Levitt, Michela Deleidi, Miriam Merad, Morten Meldal, Mourad Topors, Murali Venkatesan, Nathan K LeBrasseur, Niklas Anzinger, Peter Fedichev, Paul Kohlhaas, Peter J Mullen, Priya Singhal, Rafael de Cabo, Riekelt H Houtkooper, Rusty Montgomery, Ryan Smith, Sharon Rosenzweig-Lipson, Sergey Jakimov, Steve Horvath, Steven Austad, Thomas A Rando, Todd White, Tom Zuber, Tomaz Rozmaric, Tony Wyss-Coray, Tuomas Tammela, Vadim N Gladyshev, Vanessa V C Sinatti, Weilan Wang, William Harborne, Xiaodong Liu, Xing Li Wang, Yousin Suh, Yuta Lee, Zane Koch, Alex Zhavoronkov, Morten Scheibye-Knudsen, Daniela Bakula

      Aging.

    • Restriction of Individual Branched-Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer’s Disease in 3xTg Mice

      Reji Babygirija, Cara L Green, Michelle M Sonsalla, Izabelle Marie F Le, Fan Xiao, Sarah Yandell, Mariah F Calubag, Michaela E Trautman, Anna Tobon, Ryan Matoska, Chung-Yang Yeh, Charles I Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A Knopf, Michael J Rigby, David A Harris, Mark P Keller, Alan D Attie, Luigi Puglielli, Cholsoon Jang, Dudley W Lamming

      Advanced science (Weinheim, Baden-Wurttemberg, Germany).

    • Past, present and future perspectives on the science of aging

      Fabrisia Ambrosio, Maxim N Artyomov, Steven N Austad, Nir Barzilai, Juan Carlos Izpisua Belmonte, Daniel W Belsky, Bérénice A Benayoun, Anne Brunet, Handan Melike Dönertaş, Dena B Dubal, Evandro F Fang, Jerome N Feige, Linda P Fried, David Furman, Xu Gao, Vadim N Gladyshev, Vera Gorbunova, Myriam Gorospe, Jing-Dong J Han, Oskar Hansson, Eiji Hara, Steve Horvath, Nancy Y Ip, George A Kuchel, Matt Kaeberlein, Dudley W Lamming, Becca R Levy, Guang-Hui Liu, Jinkook Lee, Terrie E Moffitt, Tohru Minamino, Linda Partridge, Parminder Raina, Thomas A Rando, John W Rowe, Michal Schwartz, Andrew J Scott, Felipe Sierra, David A Sinclair, Charlotte E Teunissen, Bruno Vellas, Eric Verdin, Keenan A Walker, Ashley E Webb, Tony Wyss-Coray, Ming Xu, Jin-Tai Yu, Alex Zhavoronkov, Yahyah Aman, Anna Kriebs, Qingzhong Ren, Hannah Walters, Sebastien Thuault

      Nature aging.

    • The Sixth Annual Symposium of the Midwest Aging Consortium

      Ines Sturmlechner, Sarah A Ashiqueali, Hélène Martini, Karla Valdivieso, Ana Catarina Franco, Prashanth Guthikonda, Andrew J Dosch, Luis I Prieto, Niels C Asmussen, Amanda S Latham, James T Redden, Ethan A Leitschuh, Douglas G Mashek, João F Passos, Jhonny Rodriguez-Lopez, T Blake Monroe, David A Bernlohr, Paul D Robbins, Bailey A Knopf, Dudley W Lamming, Matthew J Johnston, Holly M Brown-Borg, Spencer A Tye, Timothy W Rhoads, David M Gate, Bennett G Childs, Darren J Baker, Xinna Li, In Hwa Jang, Christina D Camell, Zachary Miller, Hemali Phatnani, Adam R Konopka, Andrew J Haak, Natalia Vanegas-Avendano, Ramya N Akula, Ajinkya R Limkar, William A Ricke, Scott F Leiser, Jacinta Correia, Hua Bai, Szczepan Olszewski, Kenneth L Seldeen, G R Scott Budinger, Luisa C Morales-Nebreda, Deborah R Winter, Shelly K McCrady-Spitzer, Rozalyn M Anderson, Maria M Mihaylova, Mauricio Rojas, Ana L Mora, Nathan K LeBrasseur, Marissa J Schafer

      The journals of gerontology. Series A, Biological sciences and medical sciences.

    • Depletion of individual dietary amino acids induce distinct metabolic and chromatin states

      Spencer A Haws, Yang Liu, Cara L Green, Krittisak Chaiyakul, Pragyan Mishra, Reji Babygirija, Eric A Armstrong, Anusha T Mehendale, Irene M Ong, Dudley W Lamming, John M Denu

      The Journal of biological chemistry.

    • Ketogenesis is Dispensable for the Metabolic Adaptations to Caloric Restriction

      Chung-Yang Yeh, Alexis L Borgelt, Brynn J Vogt, Alyssa A Clark, Ted T Wong, Isaac Grunow, Michelle M Sonsalla, Reji Babygirija, Yang Liu, Michaela E Trautman, Mariah F Calubag, Bailey A Knopf, Fan Xiao, Dudley W Lamming

      Aging cell.

    • A low-protein diet drives short- and long-term improvements in metabolic health in a mouse model of sleeve gastrectomy

      Julia Illiano, Cara L Green, Alina Chao, Grace Zhu, Luiz Lopez, Odin Schaepkens, Cholsoon Jang, Dudley W Lamming, David A Harris

      Cell reports. Medicine.

    • Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

      Tracy L Hagemann, Michelle M Sonsalla, Cora Luzinski, Fernando Zacahua, David A Harris, Dudley W Lamming, Albee Messing

      Annals of clinical and translational neurology.

    • Lifelong restriction of dietary valine has sex-specific benefits for health and lifespan in mice

      Mariah F Calubag, Ismail Ademi, Cara L Green, Hashan S M Jayarathne, Dulmalika N H Manchanayake, Sandra M Le, Penelope Lialios, Lucia E Breuer, Shoshana Yakar, Reji Babygirija, Michelle M Sonsalla, Isaac Grunow, Chung-Yang Yeh, Yang Liu, Bailey A Knopf, William A Ricke, Teresa T Liu, Mariana Sadagurski, Dudley W Lamming

      bioRxiv : the preprint server for biology.

    • Dietary isoleucine content modulates the metabolic and molecular response to a Western diet in mice

      Michaela E Trautman, Cara L Green, Michael R MacArthur, Krittisak Chaiyakul, Yasmine H Alam, Chung-Yang Yeh, Reji Babygirija, Isabella James, Michael Gilpin, Esther Zelenovskiy, Madelyn Green, Ryan N Marshall, Alexander Raskin, Michelle M Sonsalla, Victoria Flores, Judith A Simcox, Irene M Ong, Kristen C Malecki, Cholsoon Jang, Dudley W Lamming

      Molecular metabolism.

    • Restriction of individual branched-chain amino acids has distinct effects on the development and progression of Alzheimer’s disease in 3xTg mice

      Reji Babygirija, Cara L Green, Michelle M Sonsalla, Fan Xiao, Mariah F Calubag, Michaela E Trautman, Anna Tobon, Ryan Matoska, Chung-Yang Yeh, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A Knopf, Michael J Rigby, Luigi Puglielli, Dudley W Lamming

      bioRxiv : the preprint server for biology.

    • Fasting is required for many of the benefits of calorie restriction in the 3xTg mouse model of Alzheimer’s disease

      Reji Babygirija, Jessica H Han, Michelle M Sonsalla, Ryan Matoska, Mariah F Calubag, Cara L Green, Anna Tobon, Chung-Yang Yeh, Diana Vertein, Sophia Schlorf, Julia Illiano, Yang Liu, Isaac Grunow, Michael J Rigby, Luigi Puglielli, David A Harris, John M Denu, Dudley W Lamming

      Nature communications.

    • Tissue-Specific Effects of Dietary Protein on Cellular Senescence Are Mediated by Branched-Chain Amino Acids

      Mariah F Calubag, Ismail Ademi, Isaac D Grunow, Lucia E Breuer, Reji Babygirija, Penelope Lialios, Sandra M Le, Michelle M Sonsalla, Julia A Illiano, Bailey A Knopf, Fan Xiao, Dennis Minton, Adam R Konopka, David A Harris, Dudley W Lamming

      Aging cell.

    • Rapamycin Does Not Compromise Exercise-Induced Muscular Adaptations in Female Mice

      Christian J Elliehausen, Szczepan S Olszewski, Dennis M Minton, Carolyn G Shult, Aditya R Ailiani, Michaela E Trautman, Reji Babygirija, Dudley W Lamming, Troy A Hornberger, Adam R Konopka

      Aging cell.

    Our goal is to understand how nutrient-responsive signaling pathways can be harnessed to promote health and longevity. Rapamycin, an inhibitor of the protein kinase mTOR, can improve both health and longevity in model organisms including mammals. Understanding and manipulating the mTOR signaling pathway through dietary, pharmaceutical or genetic interventions may provide insight into the treatment of age-related diseases, including diabetes, Alzheimer’s disease, cancer, and Hutchinson-Gilford Progeria Syndrome.

    Click here to view graphical abstract

    • American Federation for Aging Research Dorothy Dillon Eweson Lecture Series travel award (2025)
    • Star Educator Honor Roll, UW-Madison Dept of Medicine (2024)
    • H.I. Romnes Faculty Fellowship, UW-Madison (2024)
    • President, American Aging Association (2023-24)
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