Timothy Rhoads

Assistant Professor of Nutritional Sciences

Caloric restriction, metabolism, biology of aging, systems biology, gene expression regulation

timothy.rhoads@wisc.edu

Website

Type: Faculty Trainer, MANTP Trainer

Department: Nutritional Sciences

Assistant Professor of Nutritional Sciences
BS 2007, Gonzaga University
PhD 2012, Oregon State University

Microbial metabolism of methotrexate produces a STAT3 signaling molecule that alleviates gut inflammation

Juyeong Cho, Rebecca Danner, Woo Sung Kim, Jonathan Williams, Anshit Singh, Jiyoung A Han, Jonathan G Van Vranken, Allison S Walker, Timothy Rhoads, Snehal N Chaudhari

bioRxiv : the preprint server for biology. 2026 April 10.
Adiponectin and aging: Mechanistic insights, clinical paradox, and therapeutic horizons

Eric R McGregor, Katie J Osterbauer, Grace E Gustafson, Josef P Clark, Timothy W Rhoads, Rozalyn M Anderson

Ageing research reviews. 2026 February 14.
The Sixth Annual Symposium of the Midwest Aging Consortium

Ines Sturmlechner, Sarah A Ashiqueali, Hélène Martini, Karla Valdivieso, Ana Catarina Franco, Prashanth Guthikonda, Andrew J Dosch, Luis I Prieto, Niels C Asmussen, Amanda S Latham, James T Redden, Ethan A Leitschuh, Douglas G Mashek, João F Passos, Jhonny Rodriguez-Lopez, T Blake Monroe, David A Bernlohr, Paul D Robbins, Bailey A Knopf, Dudley W Lamming, Matthew J Johnston, Holly M Brown-Borg, Spencer A Tye, Timothy W Rhoads, David M Gate, Bennett G Childs, Darren J Baker, Xinna Li, In Hwa Jang, Christina D Camell, Zachary Miller, Hemali Phatnani, Adam R Konopka, Andrew J Haak, Natalia Vanegas-Avendano, Ramya N Akula, Ajinkya R Limkar, William A Ricke, Scott F Leiser, Jacinta Correia, Hua Bai, Szczepan Olszewski, Kenneth L Seldeen, G R Scott Budinger, Luisa C Morales-Nebreda, Deborah R Winter, Shelly K McCrady-Spitzer, Rozalyn M Anderson, Maria M Mihaylova, Mauricio Rojas, Ana L Mora, Nathan K LeBrasseur, Marissa J Schafer

The journals of gerontology. Series A, Biological sciences and medical sciences. 2025 December 22.
Aging-linked systemic lipid signature is reprogrammed by caloric restriction in rhesus monkeys

Salma I Abou Elhassan, Josef P Clark, Di Kuang, Timothy W Rhoads, Ricki J Colman, Joshua J Coon, Rozalyn M Anderson, Katherine A Overmyer

Molecular systems biology. 2025 December 10.
Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

Orion S Willoughby, Anna S Nichenko, Matthew H Brisendine, Niloufar Amiri, Shelby N Henry, Daniel S Braxton, John R Brown, Braeden J Kraft, Kalyn S Jenkins, Adele K Addington, Alexey V Zaitsev, Steven T Burrows, Ryan P McMillan, Haiyan Zhang, Spencer A Tye, Charles P Najt, Siobhan E Craige, Timothy W Rhoads, Junco S Warren, Joshua C Drake

Molecular metabolism. 2025 November 26.
Caloric Restriction Reprograms Adipose Tissues in Rhesus Monkeys

Josef P Clark, Timothy W Rhoads, Sean J McIlwain, Michael A Polewski, Derek M Pavelec, Ricki J Colman, Rozalyn M Anderson

Aging cell. 2025 October 3.
Ulk1(S555) inhibition alters nutrient stress response by prioritizing amino acid metabolism

Orion S Willoughby, Anna S Nichenko, Matthew H Brisendine, Niloufar Amiri, Shelby N Henry, Daniel S Braxton, John R Brown, Braeden J Kraft, Kalyn S Jenkins, Adele K Addington, Alexey V Zaitsev, Steven T Burrows, Ryan P McMillan, Haiyan Zhang, Spencer A Tye, Charles P Najt, Siobhan E Craige, Timothy W Rhoads, Junco S Warren, Joshua C Drake

bioRxiv : the preprint server for biology. 2025 July 9.
Caloric restriction reprograms adipose tissues in rhesus monkeys

Josef P Clark, Timothy W Rhoads, Sean J McIlwain, Michael A Polewski, Derek M Pavelec, Ricki J Colman, Rozalyn M Anderson

bioRxiv : the preprint server for biology. 2025 March 17.
Neuron-specific isoform of PGC-1α regulates neuronal metabolism and brain aging

Dylan C Souder, Eric R McGregor, Josef P Clark, Timothy W Rhoads, Tiaira J Porter, Kevin W Eliceiri, Darcie L Moore, Luigi Puglielli, Rozalyn M Anderson

Nature communications. 2025 February 28.
Geroprotector drugs and exercise: friends or foes on healthy longevity?

Christian J Elliehausen, Rozalyn M Anderson, Gary M Diffee, Timothy W Rhoads, Dudley W Lamming, Troy A Hornberger, Adam R Konopka

BMC biology. 2023 December 9.
Mitochondrial regulator PGC-1a in neuronal metabolism and brain aging

Dylan C Souder, Eric R McGregor, Timothy W Rhoads, Josef P Clark, Tiaira J Porter, Kevin Eliceiri, Darcie L Moore, Luigi Puglielli, Rozalyn M Anderson

bioRxiv : the preprint server for biology. 2023 October 9.
The Third Annual Symposium of the Midwest Aging Consortium

Andrea Keller, Hua Bai, Scott Budinger, Susan Eliazer, Malene Hansen, Adam R Konopka, Luisa Morales-Nebreda, Charles P Najt, Veena Prahlad, Stella Victorelli, Colby J Vorland, Rong Yuan, Timothy W Rhoads, Maria M Mihaylova

The journals of gerontology. Series A, Biological sciences and medical sciences. 2023 October 7.
Ceramides are early responders in metabolic syndrome development in rhesus monkeys

Alex B Smith, Jonah P Schill, Ruth Gordillo, Grace E Gustafson, Timothy W Rhoads, Maggie S Burhans, Aimee T Broman, Ricki J Colman, Philipp E Scherer, Rozalyn M Anderson

Scientific reports. 2022 June 15.
Caloric restriction has a new player

Timothy W Rhoads, Rozalyn M Anderson

Science (New York, N.Y.). 2022 February 10.
Metabolism in the Midwest: research from the Midwest Aging Consortium at the 49<sup>th</sup> Annual Meeting of the American Aging Association

Michaela E Murphy, Akilavalli Narasimhan, Alexis Adrian, Ankur Kumar, Cara L Green, Carolina Soto-Palma, Chathurika Henpita, Christina Camell, Christopher S Morrow, Chung-Yang Yeh, Claire E Richardson, Cristal M Hill, Darcie L Moore, Dudley W Lamming, Eric R McGregor, Heather A Simmons, Heidi H Pak, Hua Bai, John M Denu, Josef Clark, Judith Simcox, Kishore Chittimalli, Korbyn Dahlquist, Kyoo-A Lee, Mariah Calubag, Mark Bouska, Matthew J Yousefzadeh, Michelle Sonsalla, Reji Babygirija, Rong Yuan, Tadataka Tsuji, Timothy Rhoads, Vinal Menon, Yagna Pr Jarajapu, Yun Zhu

GeroScience. 2021 October 29.

Work in the GERAM (Gene Expression Regulation of Aging and Metabolism) lab, directed by Dr. Rhoads, focuses on understanding the molecular regulation of aging and metabolism through the use of caloric restriction (CR). CR is a dietary intervention and model of delayed aging; CR results in extended lifespan in numerous model organisms. This is of direct relevance for human health, as advanced age is the largest risk factor for numerous chronic diseases – cancer, diabetes, cardiovascular disease, and neurodegeneration, to name a few. However, the molecular mechanisms connecting reduced caloric intake with enhanced longevity and reduced chronic disease vulnerability remain poorly understood. The GERAM lab focuses on mechanisms of gene expression regulation, including protein post-translational modification, mRNA processing, and expression regulation via endogenous small RNA. Tools used include both wet lab and dry lab analytical methods, with a substantial interest in integrative models that produce systems-level insights.